At this time there is only the ability to mass add applications for users. If you navigate to Admin -> Users and select all users that need to be updated (or choose all if this will apply to everybody), then click on the Actions button, you should see an option for Add Applications.
Leaving an application unchecked does not remove the application from a user that already has it. Ticketing Applications are not available here and must be managed through the individual ticketing application. All users have access to Client Portal automatically.
A mass remove function is not currently available at this time.
I hope this fully explains the abilities and process to make mass editions to application access. If you have any further questions please let us know.